4591 M-リボミック 2019-05-14 15:00:00
2019年3月期第4四半期決算説明資料 [pdf]

        1
4   0       25
                                  0                1 23


▷ 6,3           /0/ R            C Q G                        A   3

    •                         7 712 7      B              Q

    •   F h              Q

    •                    Qu      5w

    •                M                Qw



▷             UC                      d C R M             w DeH
                s        w

▷       ad -)       ST       C             M       w DR       C   Q
        I y              w
▷       3 7( t P                               D    t     s
     031


.2
    142
      0.   9
3
                            B
            B       D
                                          7


                        5       D        E9     5


        5       5       5
                                          8G6                9
    E                   5           5

L       5       5       5
M       5       5       5


                            1            G 9            5
                        5   3           - 0 A       P   R2   R
                                          4
                      4 9
            4 9   4
                                   1

                      7   5,       -2   0




    8


                      7   5

    8
                              63
8
                               5

        8
    1   27
        0.   9
3
 1



RBM-007   FGF2        (AMD)


RBM-007   FGF2                     AMED (   8)


RBM-007   FGF2


RBM-004   NGF


RBM-003   Chymase                            2


RBM-010   ADAMTS-5


RBM-006   Autotaxin


RBM-001   Midkine


 1


RBM-101   IgG                 Fc
                        B


                        7 1 20                      -            / 8
,o
(u                                    p.694             ynN
u     p10.                       2A       F       F A   3 I 0D       230 .CC   F AN
u                            10.              c     lg           N
     / A    8D                                            a            p           g
,u   /64        vs                    N                 4266/ 7 AA         /. N
                g       R        N                            lh     le    c   N
u               g       TV
u                       Oci          gN                   t
 o
u     Oci           g                         r           Pci        gN        t
u     Pci           g                         w               ci     gN        t
)u         ci       g                 t

           S u               5
    12

    o
    t     phle                    m                 RT                Jn
           T         u
    o
    t     c   m          l   d    sR                     J   hci               N
                 T   u
    t    -0-376 Sy               Tr     R                J        y


0

    o
    t 5.3   T M         Sy                  n                RT            T
      18 8 A A  8 ..5     ,
    o
    t    i aH hci S                         uSy              n     n   RT
          T
      2   8 3A 9 8C 7 C8B 4 9     9 -9 :D       ,
            0


2   1


    R                 9 2-                           TB
                     G     JM8    2       F                   B       7
                6
                    9145                       T   -45    A
            S        9 0         F             G JM8      I       B
        7            6            7             B




            ADE                       B        9
            ADE~             9            DC        9         B
    9                    7
                                                                                 (        )
                         m




                                                                   M   C    ul   n    S
    rm
                                                                  sF       mG


     i

c




    5.0/ t       F           V       H     a      V          C    eE   Ha        GD
     2-              N                     dE                 o
    1    - 36A                   ,   8:A   : 86: 26 8   68
                              3   1


    )     ,7 1 2          ) 31/           ( VL G y        GFA
▷    VM           A       ED   F V                        A
    A                     M  c M
▷       M             i           A       M     A    u        A
▷         M               a
s




                                                          +


              n   M       M           e



            l     t       M

          (l L                )       L             M A
                        2


▷                   F       RE         2
▷        4P G           G          1
                                           )   O




        TGFβ2               V
        FGF2    C

                (
                            FGF2



                        P              P           TM


        VEGF
        FGF2


    R                                  E   R
                        RE
        RNG                                         UYS

                 O




               B                 1B B                    1        DB              .      A                 %    C
                BC             20    5) B                     B                       A B         F B8 .C B 8F CB
        5F8B CD   B DE F            2                    20       B                             C F    5C F I EF
                                                                                      5.
              DC EECD                                         2                                      , D FCD
                                                                              0     8    BF D
                                                                                  DC EECD
    .           %0                 MK           I             QO
                     $ S
                    5
                      D        )       5)
           2      7 E      )       ,
         .2        A C 18 8A D8             RP      ON       hc       U   M
$       5F8       e       aY   ilk          f   d
                 1                                                               ()(               HI


    HI       1   2        /       S                                  P               P
    S                 C       M                       GB                                   P M 3. v                        tw
    S                                                                                ci    h :/10 d              R         u
                      C       M                      GB                                d        ce             ig
    SW
                      C       M                      GB                              U     V      b

     I
       l o        M       A           DO        DM                                                 . .D        .
    Ulsprsm
                 6 MD         F            FM    M 3       D    F1       J           G     M       . 2     F       FG
    nk   V
                 6 MD         F            FM    M 3       D    F1       J            G    M       . 3     B       M   C   B

                 ,                6 MD                    D M        F       M       E             .       C           6



                                            wc            h          a
         y                    Tnr          s         gd
                                                                cfh              d             U       d       V



)
20 1                0 -/-() H         7



e           Day 1   Day 7             Week 4                      Month 2


    T                        H                            R   e

                                     fh          a                twr


    mtw

                                         I   M        -       B

    1.12               0
    1.12               0
    1.12               0


    mtw         s
g       i                   3 , 72   0           Cy   o
            S                   v
▷ a dG         1.       ( e            R
          09   BB 4 2    A    B 2A49   1B       2    . 9 92   8F


▷ m   G         (

▷   cdG         2 8 8          42       2            B42AA 8       2
          24            2 2             A           2B -A      9

              24 A      2 2        A        2        2         B

          A     2       B 2B

▷ m   G          A           9B        lh

                T                 aO TV                            gfk

          o ainb
▷   s               o1              o1   tb         l
▷                   -           -        -
▷                           o G               r




                FGF2
                                             FGF9   FGF2
         FGF9




         i              9       1                          1
    Fc          l           w   h        wa
                                     0   6


▷           1 6          0
▷ 6




    6   )   23       7   C       C




             %               C


                 %
                                       5


▷ e      rw f   B                  1           55
▷   AR      -, B    05 5   1   5       0   1        15   1   5   05   52

▷ dip       tllb D                         O             Mbo               AT
         -,  p                             M m
▷ g        -,              ABhanSA




            s
                  -                     1                     0


      ut      opi 09 D56 = 9 19 5= 19                              011 a c

d     b    em     kʼ             lP     nvM



                      )
                                                     .        :B

                                                         2-         5= 9 0   B5 <   5 5=
B9




           5= 9           : <:              : <:

                                      ryz

3/1       Rry S                  R d               b eRgs
                               -




        Angiotensin I                        proMMP-9




        Angiotensin II                         MMP-9

                                                        3
                         TGF-β       TGF-β
                         precursor




                                                            0   3


▷   2
▷                               2
    -                        3       R
            0


M
        R

    M
                    C


                                 -
    M       B   0
                                 4
                         B
                             2
                    03
        1   2
            0.   9
5   3
       7                                           7


2/ 1           / - -() -        0
       F
               s               Rl
               s        h


2/ 1       -       0
       F
                           h            C   BAD
                       P                7 837 8        Nm   hn   t   aI
                           h        e         1/   O
                       0 29         h   d

           F
                       0 29         h       0628
                2    -


           -

       V             G                          G
    E C)                                                    E C)               O
                         E C)
                                                            T27 D

                                                                b      b       aI


                        mTw
     lr    hp        -        RT           7C       C       B7AF O         4        (
                                C   B7AF

                    c                           Mc

                    y    R          O           I                b     T   o       vO
           t
                        3 5                                  T         v
                    GN~n                                G       ~n
                    40 3 0                                  7    eRT           i


(
*

)                                          a

(




                                                                        427
                     (                )                *

    4   0       eD   AR   c   02764 14842735 /   74M   )   F   D   MD
    h       (
        o                                  l          k      R


        r                        R            9 10        p

                             :       5                yt         a                           hg
                              GL     5            a               m                      u            hg

                             :       5        9 10               4J   D HN     LB    N

                              GL     5

                             •        yt         sV   o                      S       o
    :       5                •         W       o   M k            V
                             •                        c                      v                    S
                             •        R                                 a        o

                             •                 yte
                             •            e
    7,5
                             •       M i                  e


            5 GA      EF      -ECCJD L     L 2   B 3EJGD B       k      ~    e     n
            9 H ED   Dn    k    ~   7E      n    E G Hn 7        D GEDn      k DDJ B 7 FEG   e    9 10
              v      V   5 e®                        r              n
                            n
)
            ED          .0  P 4- lfP
            S            VnaM iN


                            S    VOR   cna                        T    Y                   kna
    na          e               EGB  L4      )                    , 8 9 - , CA               I            (
                              1 1 .,1 FG HH G C               H    2  29 FG HH G C         H

        a               7I L      L >                             3 GD
        ax              6 M LD                                         >
                                                                  3763          1 4 O L B LDGB 1 >L
        b               1 MD L R         GLD 8021         IL F
                                                                   1             GLD G

        b           S   8        33                               8          3

                                gc       h         8021       m              ~                  p     f
        nr
                        t            f            l                   b          s
    e                   N L     50                                    P     50       d      U
    e       d           i                ovw                      ovw
     IA     GL              $$ 5D D G                                  ) 5D D G
    5D      L G         - %      D D G       IA   GL      y   U            ( 5D D G
         P LP                                                     %$        $
$
                    3
        3
        1


    1           3


            3




3
3
    01   20   4